{"created":"2023-05-15T14:47:08.031012+00:00","id":10870,"links":{},"metadata":{"_buckets":{"deposit":"8a5febbe-a096-4ae6-b568-781a541aefa8"},"_deposit":{"created_by":11,"id":"10870","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"10870"},"status":"published"},"_oai":{"id":"oai:ksu.repo.nii.ac.jp:00010870","sets":["14:226:1080"]},"author_link":["22724","22301"],"control_number":"10870","item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-03-10","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"131","bibliographicPageStart":"121","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"京都産業大学総合学術研究所所報"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"がん幹細胞は，抗がん剤や放射線治療に極めて高い耐性を示し，治療後も残存してがん細胞を生み続けて再発を引き起こす。従って，がん幹細胞性を制御している機構を解明し，その対策を講じることが，がんの根治的治療に重要である。我々はこれまでに，糖鎖の発現とがん幹細胞性との関連について研究を展開し，ヒアルロン酸糖鎖の過剰産生が，糖代謝中心プログラムのヘキソサミン合成経路（HBP）の代謝流束（フラックス）を加速して，がん幹細胞性の促進に働くことを明らかにしてきた。\nHBP は，糖供与体UDP-N- アセチルグルコサミン（UDP-GlcNAc）の供給を通じて，タンパク質の糖鎖修飾を制御し，細胞内のシグナル伝達や転写調節，エピジェネティクスなど細胞機能の広範な調節に働く。しかしながら，このHBP 代謝流速の加速が，がん幹細胞性の制御に働く詳細な機構については，依然として明らかではない。また，UDP-GlcNAc の細胞内動態をリアルタイムに計測する手法が開発されていないため，UDP-GlcNAc の細胞内動態が細胞シグナルの調節に働く機構は，十分に理解されていない。今回我々は，HBP 代謝振動による細胞内UDP-GlcNAc 濃度の周期的な変化が，下流シグナルの発信とがん幹細胞性の制御に働くという仮説を立て，数理モデルよる検証を行った。","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"京都産業大学総合学術研究所"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11879037","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348-8465","subitem_source_identifier_type":"PISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"白岡, 航平","creatorNameLang":"ja"},{"creatorName":"シラオカ, コウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"SHIRAOKA, Kohei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22724","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"板野, 直樹","creatorNameLang":"ja"},{"creatorName":"イタノ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"ITANO, Naoki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22301","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-07"}],"displaytype":"detail","filename":"KSUSGKS_17_121.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KSUSGKS_17_121.pdf","url":"https://ksu.repo.nii.ac.jp/record/10870/files/KSUSGKS_17_121.pdf"},"version_id":"365b2ad9-ed4e-4c8f-b1c2-fbd927ffbd9f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"乳がん","subitem_subject_scheme":"Other"},{"subitem_subject":"がん幹細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒアルロン酸","subitem_subject_scheme":"Other"},{"subitem_subject":"ヘキソサミン合成経路","subitem_subject_scheme":"Other"},{"subitem_subject":"数理モデル","subitem_subject_scheme":"Other"},{"subitem_subject":"シミュレーション","subitem_subject_scheme":"Other"},{"subitem_subject":"Breast cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cancer stem cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hyaluronan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hexosamine biosynthetic pathway","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mathematical model","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Simulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"がん幹細胞性を調節するヘキソサミン合成経路の数理モデル","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がん幹細胞性を調節するヘキソサミン合成経路の数理モデル","subitem_title_language":"ja"},{"subitem_title":"Mathematical model of hexosamine biosynthetic pathway governing cancer cell stemness","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"11","path":["1080"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-04-07"},"publish_date":"2023-04-07","publish_status":"0","recid":"10870","relation_version_is_last":true,"title":["がん幹細胞性を調節するヘキソサミン合成経路の数理モデル"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-07-13T01:02:57.321754+00:00"}