{"created":"2023-05-15T14:42:12.054951+00:00","id":2366,"links":{},"metadata":{"_buckets":{"deposit":"ee5b56ca-19ad-451d-8d19-3082752de389"},"_deposit":{"created_by":3,"id":"2366","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2366"},"status":"published"},"_oai":{"id":"oai:ksu.repo.nii.ac.jp:00002366","sets":["15:18:22"]},"author_link":["6237","6238","6239","6240","14821","14807","19346"],"control_number":"2366","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"280","bibliographicPageStart":"275","bibliographicVolumeNumber":"420","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Prohibitins (prohibitin-1 and -2) comprise a family of highly conserved proteins that are mainly localized to mitochondria. Recent studies showed that prohibitins are up-regulated upon T cell activation and play an essential role in maintaining mitochondrial homeostasis. In the present study, we found that a considerable proportion of prohibitin-1 and -2 induced in response to T cell activation was expressed on the surface of activated T cells. When mouse and human T cells were stimulated with PMA and ionomycin, prohibitins expressed on the cell surface were increased significantly, peaking at 48 h after stimulation. Stimulation of mouse T cells with anti-CD3 and anti-CD28 antibodies also remarkably induced the cell surface expression of prohibitins. Their expression on the cell surface was also detected in T cell leukemia cells such as Jurkat cells. In Jurkat cells, prohibitin-1 and -2 were co-localized with CD3 on the cell surface, and anti-CD3 antibody-induced signaling, the MAP kinase cascade, was inhibited on treatment with protein A magnetic beads co-conjugated with anti-CD3 antibody and anti-prohibitin-1 or anti-prohibitin-2 antibody. These results suggest that prohibitins expressed on the surface of activated T cells are involved in the T cell receptor-mediated signaling cascade.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Inc."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-291X","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"YURUGI, Hajime","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6237","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TANIDA, Shuhei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6238","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ISHIDA, Akiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6239","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"AKITA, Kaoru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6240","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TODA, Munetoyo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"14821","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"INOUE, Mizue","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"14807","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NAKADA, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19346","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-09-30"}],"displaytype":"detail","filename":"BBRC_420_275.pdf","filesize":[{"value":"10.6 MB"}],"format":"application/pdf","license_note":"Hajime Yurugi, Shuhei Tanida, Akiko Ishida, Kaoru Akita, Munetoyo Toda, Mizue Inoue, Hiroshi Nakada.Expression of prohibitins on the surface of activated T cells. Biochemical and Biophysical Research Communications. Elsevier Inc. 2012, 420, p.275-280","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BBRC_420_275.pdf","url":"https://ksu.repo.nii.ac.jp/record/2366/files/BBRC_420_275.pdf"},"version_id":"984abb83-41a7-459b-9a2a-fcc3bf8ea97e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Prohibitin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"T cell regulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Signal transduction","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Expression of prohibitins on the surface of activated T cells.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of prohibitins on the surface of activated T cells.","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"3","path":["22"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-09-30"},"publish_date":"2017-09-30","publish_status":"0","recid":"2366","relation_version_is_last":true,"title":["Expression of prohibitins on the surface of activated T cells."],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-22T03:35:21.472950+00:00"}