{"created":"2023-05-15T14:42:19.354015+00:00","id":2568,"links":{},"metadata":{"_buckets":{"deposit":"b84cba0c-44ec-4a06-8d59-c477434741a0"},"_deposit":{"created_by":3,"id":"2568","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2568"},"status":"published"},"_oai":{"id":"oai:ksu.repo.nii.ac.jp:00002568","sets":["14:179:183"]},"author_link":["19346"],"control_number":"2568","item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-07","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"14","bibliographicPageStart":"1","bibliographicVolumeNumber":"4","bibliographic_titles":[{"bibliographic_title":"京都産業大学先端科学技術研究所所報"},{"bibliographic_title":"The bulletin of the Research Institute of Advanced Technology Kyoto Sangyo University","bibliographic_titleLang":"en"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"上皮性癌細胞の産生するムチンは，担癌患者の癌組織や血流中に分泌され，様々な免疫系細胞と相互作用することがわかってきた．その中で，単球／マクロファージ上の受容体であるスカベンジャーリセプターにムチンが結合することにより，同細胞のシクロオキシゲナーゼ2が誘導され，プロスタグランジンE_2の産生の亢進が明らかとなった．プロスタグランジンE_2は，免疫抑制，アポトーシスの抑制及び血管新生などの生理作用をもち，癌細胞の増殖・進展に有利な状況をもたらすものと考えられる．事実，マウス乳癌由来細胞株でムチン産生細胞TA3-Haとムチン非産生細胞TA3-Stにおける腫瘍組織形成を比較することにより，ムチンを起点とするカスケードの存在と腫瘍組織の形成への関与が明確となった．","subitem_description_type":"Other"}]},"item_2_description_15":{"attribute_name":"表示順","attribute_value_mlt":[{"subitem_description":"1","subitem_description_type":"Other"}]},"item_2_description_16":{"attribute_name":"アクセション番号","attribute_value_mlt":[{"subitem_description":"KJ00003144680","subitem_description_type":"Other"}]},"item_2_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"研究論文","subitem_description_type":"Other"}]},"item_2_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Paper","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11815191","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-3980","subitem_source_identifier_type":"PISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"京都産業大学工学部生物工学科"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中田, 博","creatorNameLang":"ja"},{"creatorName":"ナカダ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-28"}],"displaytype":"detail","filename":"KJ00003144680.pdf","filesize":[{"value":"3.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00003144680.pdf","url":"https://ksu.repo.nii.ac.jp/record/2568/files/KJ00003144680.pdf"},"version_id":"aa309890-1701-463e-b53a-9a48eb611645"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"腫瘍形成におけるムチンの生物学的意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腫瘍形成におけるムチンの生物学的意義","subitem_title_language":"ja"},{"subitem_title":"シュヨウ ケイセイ ニオケル ムチン ノ セイブツガクテキ イギ","subitem_title_language":"ja-Kana"}]},"item_type_id":"2","owner":"3","path":["183"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-01-28"},"publish_date":"2018-01-28","publish_status":"0","recid":"2568","relation_version_is_last":true,"title":["腫瘍形成におけるムチンの生物学的意義"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-29T00:57:22.807713+00:00"}