{"created":"2023-05-15T14:42:38.464386+00:00","id":2991,"links":{},"metadata":{"_buckets":{"deposit":"bc2b945b-dcc5-43b5-aa60-0b85cc00f7ba"},"_deposit":{"created_by":3,"id":"2991","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2991"},"status":"published"},"_oai":{"id":"oai:ksu.repo.nii.ac.jp:00002991","sets":["14:226:230"]},"author_link":["7781","21695"],"control_number":"2991","item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-07","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"136","bibliographicPageStart":"131","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"京都産業大学総合学術研究所所報"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"喫煙は慢性閉塞性肺疾患（COPD），および，喘息などのリスク因子として広く知られている。喫煙は気道組織に炎症を引き起こし，それに伴い，平滑筋の収縮過敏を誘発する。その結果，気道の狭窄が生じることにより，COPDや喘息などの病態発現に関与していると考えられている。しかし，喫煙がどのようなメカニズムにより気道平滑筋の収縮過敏を引き起こすのかについては，いまだ十分に明らかにされていない。そこで，我々はマウスにタバコ煙を暴露することにより作製した喫煙モデルマウスを用い，上記の未解決問題に取り組んでいる。今回，我々は手始めに，マウス気管平滑筋標本における張力測定法の確立に取り組み，70mM K⁺溶液やcarbacholによる収縮反応，および，isoprenalineによる弛緩反応の記録に成功した。","subitem_description_type":"Other"}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"It is well known that cigarette smoke is an important risk factor for chronic obstructive pulmonary disease（COPD）and asthma. It has been suggested that cigarette smoke exposure can induce airway hyperreactivity, which is associated with airway inflammation. The hayperreactivity can contribute to airway narrowing in patients with COPD and asthma. However, little is known about underlying mechanisms of the airway hyperreactivity induced by cigarette smoke. Therefore, we are addressing the above issue using the mice that are exposed to cigarette smoke. In the present study, we developed a method for recording mechanical activity in mouse tracheal smooth muscles. We successfully recorded contractions induced by isotonic 70mM K⁺ and carbachol and relaxations induced by isoprenaline in the mouse tracheal preparations with our recording method.","subitem_description_type":"Other"}]},"item_2_description_15":{"attribute_name":"表示順","attribute_value_mlt":[{"subitem_description":"12","subitem_description_type":"Other"}]},"item_2_description_16":{"attribute_name":"アクセション番号","attribute_value_mlt":[{"subitem_description":"KJ00008753499","subitem_description_type":"Other"}]},"item_2_description_2":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"研究ノート","subitem_description_type":"Other"}]},"item_2_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Note","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11879037","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348-8465","subitem_source_identifier_type":"PISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"京都産業大学総合生命科学部"},{"subitem_text_value":"京都産業大学総合生命科学部"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"棚橋, 靖行","creatorNameLang":"ja"},{"creatorName":"タナハシ, ヤスユキ","creatorNameLang":"ja-Kana"},{"creatorName":"TANAHASHI, Yasuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"竹内, 実","creatorNameLang":"ja"},{"creatorName":"タケウチ, ミノル","creatorNameLang":"ja-Kana"},{"creatorName":"TAKEUCHI, Minoru","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-28"}],"displaytype":"detail","filename":"KJ00008753499.pdf","filesize":[{"value":"788.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00008753499.pdf","url":"https://ksu.repo.nii.ac.jp/record/2991/files/KJ00008753499.pdf"},"version_id":"c8fbf942-06cf-4504-9123-6b21617f59fc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"喫煙","subitem_subject_scheme":"Other"},{"subitem_subject":"気道平滑筋過敏反応性","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症","subitem_subject_scheme":"Other"},{"subitem_subject":"慢性閉塞性肺疾患(COPD)","subitem_subject_scheme":"Other"},{"subitem_subject":"喘息","subitem_subject_scheme":"Other"},{"subitem_subject":"cigarette smoke","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hyperreactivity of airway smooth muscles","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chronic obstructive pulmonary disease(COPD)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"asthma","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"マウス気管平滑筋標本における張力測定法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウス気管平滑筋標本における張力測定法の開発","subitem_title_language":"ja"},{"subitem_title":"Development of a method for recording the changes of tension in mouse tracheal smooth muscles","subitem_title_language":"en"},{"subitem_title":"マウス キカン ヘイカツ キン ヒョウホン ニオケル チョウリョク ソクテイ ホウ ノ カイハツ","subitem_title_language":"ja-Kana"}]},"item_type_id":"2","owner":"3","path":["230"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-01-28"},"publish_date":"2018-01-28","publish_status":"0","recid":"2991","relation_version_is_last":true,"title":["マウス気管平滑筋標本における張力測定法の開発"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-06T05:53:30.260314+00:00"}