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Expression of prohibitins on the surface of activated T cells.
http://hdl.handle.net/10965/938
http://hdl.handle.net/10965/938c06905b4-4e30-4b49-abc0-a23b57ea8932
| 名前 / ファイル | ライセンス | アクション |
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BBRC_420_275.pdf (10.6 MB)
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Hajime Yurugi, Shuhei Tanida, Akiko Ishida, Kaoru Akita, Munetoyo Toda, Mizue Inoue, Hiroshi Nakada.Expression of prohibitins on the surface of activated T cells. Biochemical and Biophysical Research Communications. Elsevier Inc. 2012, 420, p.275-280
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-09-30 | |||||
| タイトル | ||||||
| タイトル | Expression of prohibitins on the surface of activated T cells. | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Prohibitin | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | T cell regulation | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Signal transduction | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
YURUGI, Hajime
× YURUGI, Hajime× TANIDA, Shuhei× ISHIDA, Akiko× AKITA, Kaoru× TODA, Munetoyo× INOUE, Mizue× NAKADA, Hiroshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Prohibitins (prohibitin-1 and -2) comprise a family of highly conserved proteins that are mainly localized to mitochondria. Recent studies showed that prohibitins are up-regulated upon T cell activation and play an essential role in maintaining mitochondrial homeostasis. In the present study, we found that a considerable proportion of prohibitin-1 and -2 induced in response to T cell activation was expressed on the surface of activated T cells. When mouse and human T cells were stimulated with PMA and ionomycin, prohibitins expressed on the cell surface were increased significantly, peaking at 48 h after stimulation. Stimulation of mouse T cells with anti-CD3 and anti-CD28 antibodies also remarkably induced the cell surface expression of prohibitins. Their expression on the cell surface was also detected in T cell leukemia cells such as Jurkat cells. In Jurkat cells, prohibitin-1 and -2 were co-localized with CD3 on the cell surface, and anti-CD3 antibody-induced signaling, the MAP kinase cascade, was inhibited on treatment with protein A magnetic beads co-conjugated with anti-CD3 antibody and anti-prohibitin-1 or anti-prohibitin-2 antibody. These results suggest that prohibitins expressed on the surface of activated T cells are involved in the T cell receptor-mediated signaling cascade. | |||||
| 書誌情報 |
en : Biochemical and Biophysical Research Communications 巻 420, p. 275-280, 発行日 2012-03 |
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| 出版者 | ||||||
| 出版者 | Elsevier Inc. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0006-291X | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
